Sofosbuvir/velpatasvir/voxilaprevir (Vosevi) for hepatitis C
Content date: 11 November 2026
A three-drug combination known as Vosevi, often used by specialists to retreat hepatitis C after previous therapy failed. Selection depends on prior medicines and liver health.
Your next step
Check your written prescription and monitoring plan. If anything is unclear, ask your care team before changing a dose.
Get urgent help: Get urgent help for new jaundice, abdominal swelling, confusion or bleeding, or fainting, a slow heartbeat or chest pain.
How to use
- The usual adult dose is one 400/100/100 mg tablet daily with food; retreatment commonly lasts 12 weeks. Follow your prescribed duration. For missed doses or vomiting after dosing, use your leaflet or ask the pharmacist; never double, and do not combine with another sofosbuvir-containing treatment without instructions.
Storage
- Follow the temperature requirement on your dispensed pack and retain the original container. Product labels can differ. Keep away from children and heat; do not leave it in a hot car.
Tests and follow-up
- Review previous treatments and genotype where relevant, with HCV RNA, liver/kidney function, HIV and hepatitis B testing. HBV can reactivate during or after treatment and needs monitoring. An undetectable HCV RNA result at least 12 weeks after treatment completion confirms cure.
Possible side effects: what to expect
- Not everyone gets side effects. Headache, tiredness, nausea or diarrhoea may occur. Take your dose with food and report ongoing diarrhoea or vomiting, especially if you cannot retain fluids or medicine; do not repeat a dose yourself.
- Serious liver deterioration can occur, particularly with advanced liver disease, so treatment selection requires liver assessment. Medication interactions and hepatitis B reactivation also need review. New jaundice, confusion or abdominal swelling warrants urgent assessment.
Important
- It contains a protease inhibitor and is unsuitable with moderate/severe liver impairment or previous decompensation such as ascites, variceal bleeding or hepatic encephalopathy. Rifampicin is contraindicated. Also review amiodarone, ciclosporin, statins, seizure medicines and St John’s wort. Separate ordinary antacids by four hours; other acid-reducing medicines require review. Discuss pregnancy and breastfeeding.
My prescribed plan - complete with the team
Brand / device: ........................ | Dose and how I take or use the medicine: ........................
Next dose: ........................ | Next blood tests: ........................
Team contact: ........................
Brand / device: ........................ | Dose and how I take or use the medicine: ........................
Next dose: ........................ | Next blood tests: ........................
Team contact: ........................
When to get help
Get urgent help for new jaundice, abdominal swelling, confusion or bleeding, or fainting, a slow heartbeat or chest pain.
Contact the clinic for persistent headache, nausea, diarrhoea or fatigue, repeated missed doses, or newly started medicines.